May 17-19, 2010 Meeting Agenda

NCI Tumor Microenvironment Network

Junior Investigator Meeting

May 17-19, 2010

         Doubletree Metropolitan Hotel
      569 Lexington Avenue
     New York, New York 10022

        http://www.metropolitanhotelnyc.com/

AGENDA

Date &Time                          Location

Monday, May 17        Doubletree Metropolitan Hotel

3:00pm                        Meet in hotel lobby; walk to Memorial Sloan-Kettering Cancer Center 

3:30pm - 4:00pm         Memorial Sloan-Kettering Cancer Center  Registration

4:00pm - 4:30pm         Introductions:  Paula Bos and Aubie Shaw, meeting Co-Chairs 

Welcome:

Eric Holland, M.D., Ph.D.

       Member of the Cancer Biology and Genetics Program,

       Director of the Brain Tumor Center,

       Memorial Sloan-Kettering Cancer Center

Opening remarks:

      Dinah Singer, Ph.D., Director, Division of Cancer Biology, NCI

      Suresh Mohla, Ph.D., Associate Director, Division of Cancer Biology, NCI

4:30pm - 5:30pm         Technology Session 1:  Intravital Imaging

                                    Speakers:

Bojana Gligorijevic (Einstein):  “Intravital imaging of primary tumors: defining microenvironments of invasion and metastasis” (15 min)

Antonia Patsialou (Einstein):  “In vivo invasion assay: characterization of the migratory tumor cells and their stromal interactions during invasion in primary tumors” (15 min) 

5:30pm - 7:30pm         “Speed Science” (2 min talks)

                                    Moderator:  Paula Bos

Speakers:  Junior Investigator attendees

7:30pm                                    Group dinner

Tuesday, May 18       Doubletree Metropolitan Hotel 

8:00am - 9:00am         Registration

                                    Continental Breakfast 

9:00am - 10:30am       Technology Session 2:  In Vitro Models and Imaging

Speakers:

Tsukasa Shibue (MIT):  “A practical approach to study the behavior of disseminated micrometastatic cancer cells” (15 min)

Cyrus M. Ghajar (Berkeley):  “Modeling the tumor microenvironment in cell culture” (10 min)

Steven Ressler (Baylor):  “Multispectral analysis of stromal marker staining of human tissue arrays” (15 min)

10:30am - 10:45am     Coffee break

10:45am - 11:45am     Keynote Speaker (45 min talk + 15 min Q&A)

Irving Weissman, M.D., Stanford University “Bone marrow derived cells”

12:00pm - 4:00pm       Group activity (boxed lunch)

4:00pm - 5:00pm         Invited Presentation (45 min talk + 15 min Q&A)

                                    David Lyden, M.D., Ph.D., Weill Cornell Medical College “Cellular and molecular mechanisms for the pre-metastatic niche”

5:00pm - 6:00pm         Invited Presentation (45 min talk + 15 min Q&A)

                                    Srinivas Nagaraj, Ph.D., H. Lee Moffitt Cancer Center “Myeloid derived suppressor cells in cancer”

6:00pm - 7:00pm         Technology Session 3:   Bone Marrow and Stem Cells                           

                                    Speakers:

                                    Michael Quante (Columbia): “Bone marrow transplantation:  bone marrow derived cells contribute to the tumor stroma” (15 min)

                                    Piero Dalerba and Ferenc Scheeren (Stanford): “Cancer stem cells: definition, phenotypic characterization, in vitro and in vivo functional analysis” (15 min)

7:00pm                        Cash bar and dinner

Wednesday, May 19  Doubletree Metropolitan Hotel 

8:00am - 9:00am         Continental breakfast 

9:00am - 10:30am       Technology Session 4:  Xenografts

Speakers:

Paula Bos and Steve Mason (MSKCC): “Metastasis modeling through xenograft and in vitro technology” (15 min) 

Stephanie Pyonteck (MSKCC): “Macrophage depletion technology” (10 min) 

Omar Franco (Vanderbilt): “Tissue recombination using renal grafting” (15 min)

Daniella Bianchi-Frias (U. Washington): “Orthotopic injection of prostate cancer cells into aged mice” (15 min) 

10:30am - 10:45am     Coffee break

10:45am - 11:45am     Invited Presentation (45 min talk + 15 min Q&A)

                                    Kornelia Polyak, M.D., Ph.D., Harvard Medical School

                                    “The role of the microenvironment in breast tumor progression” 

11:45am - 12:15pm     Establishment of the TMEN Alumni Group

12:15pm - 12:30pm     Closing remarks and adjourn

Paula Bos and Aubie Shaw, meeting Co-Chairs