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May 11-13, 2011 Agenda
2nd NCI Tumor Microenvironment Network
Junior Investigator Meeting
May 11-13, 2011
Le Meridien Cambridge-MIT Hotel
20 Sidney Street
Cambridge, MA 02139
http://www.starwoodhotels.com/lemeridien/property/overview/index.html?propertyID=3253
AGENDA
Date &Time Location
Wed., May 11 MIT campus – Koch Institute for Integrative Cancer Research at MIT
(room 76-156) 500 Main Street, Cambridge, MA 02139
1:00 Meet in hotel lobby; walk to MIT as group
1:30-2:00 Registration at MIT
2:00-2:45 Introductions: Aubie Shaw and Alexandra Naba, Meeting Co-Chairs
Welcome:
- Bob Weinberg
Whitehead Institute (Cambridge, MA, USA)
Opening remarks:
Dinah Singer, Ph.D., Director, Division of Cancer Biology, NCI
Suresh Mohla, Ph.D., Associate Director, Division of Cancer Biology, NCI
2:45-4:45 “Speed Science” (2 min talks, 1 slide)
Moderator: Aubie Shaw
Speakers: All Junior Investigator attendees
4:45-5:00 Break
Session I: Effects of cancer therapies on the tumor microenvironment
5:00-6:00 Keynote speaker: Rakesh Jain, Ph.D. (Massachusetts General Hospital, Boston, MA, USA)
(45 min seminar, 15 min Q&A)
Title: "Normalizing Tumor Microenvironment to Treat Cancer: From Mathematical Model to Mouse to Man"
6:00-7:30 Hot Topics (15 min talk + 5 min Q&A per speaker)
Ken Pitter (MSKCC): “Modeling Glioma Recurrence Following Radiation and Chemotherapy”
Nina Seitzer (Dana Farber): “Exploring the Immune System as a Target for Melanoma Therapy”
Todd Waldron (U Penn): “Myeloid Derived Suppressor Cells Promote Activation of Stromal Fibroblasts”
Steve Ressler (Baylor): “Reactive Stroma Progenitor Cells in the Human Prostate Gland”
7:30 Group dinner – all attendees will dine together at local restaurant
Date &Time Location
Thurs., May 12 Le Meridien Hotel - MIT
20 Sidney Street, Cambridge, MA 02139
8:00-9:00 Registration
Continental Breakfast
Session II: Role of gradients of soluble factors and ECM in the tumor microenvironment on metastasis
9:00-10:00 Keynote speaker: Steve Weiss, M.D. (University of Michigan, Ann Arbor, MI, USA)
(45 min seminar, 15 min Q&A)
Title: “Pericellular Proteolysis and the Regulation of the 3-Dimensional Cancer Invasion Program”
10:00-10:15 Coffee break
10:15-11:45 Hot Topics (15 min talk + 5 min Q&A per speaker)
Alexandra Naba (MIT): “How Does the Extracellular Matrix Influence Tumor Progression and Metastasis Formation?”
Mandana Veiseh (UC-Berkeley): “Use of Hyaluronan-Based Microenvironmental Probes for Profiling and Sorting Breast Cancer Cellular Heterogeneity”
Tom Long (U Washington): “Controlling the Tumor Microenvironment: A Biomaterials-Based Approach to Study Prostate Tumorigenesis”
Valerie Lebleu (BIDMC): “Vascular Targeting in Tumors Leads to Hypoxia Induced Epithelial to Mesenchymal Transition and Metastasis Mediated by c-Met Signaling Pathway”
12:00-3:00 Group activity (boxed lunch)
3-4 outdoor/indoor activities will be planned for smaller groups (TBA)
Session III: Tumor dormancy and the role of the microenvironment
3:00-4:00 Keynote speaker: Ann Chambers, Ph.D. (London Regional Cancer Program, London, Ontario, Canada)
(45 min seminar, 15 min Q&A)
Title: “Tumor Metastasis and Dormancy: Experimental Imaging studies and clinical implications”
4:00-5:15 Hot Topics (15 min talk + 5 min Q&A per speaker)
Neethan Lobo (Stanford): “Single cell PCR analysis of normal and malignant mammary epithelium”
Hernan Roca (U Michigan): “Macrophage-cancer cell interactions induce epithelial to mesenchymal transition as a mechanism of prostate cancer metastasis”
Ying Su (Dana Farber): “Myoepithelial cell differentiation defect in human breast cancer”
5:15-5:30 Coffee break
5:30-6:30 Career session I: NCI Grants
Ming Lei (NCI): “NCI grants for junior investigators” (15 min talk)
Panelists: (45 minute Q&A)
Ming Lei (NCI),
Suresh Mohla (NCI),
Sandy McAllister (Brigham and Women’s Hospital, Harvard),
Tim Padera (MGH, Harvard),
Zhe Li (Brigham and Women’s Hospital, Harvard)
6:30-7:30 Career session II: Interdisciplinary Collaborations
Douglas Lauffenburger (MIT): “Scientific collaborations in an interdisciplinary environment” (15 minute talk)
Panelists: (45 minute Q&A)
Douglas Lauffenburger (MIT),
Mikael Pittet (MGH),
Anne Carpenter (MIT),
John Quackenbush (DFCI, Harvard)
7:30 Dinner and cash bar at hotel
Date &Time Location
Fri., May 13 Le Meridien Hotel – 20 Sidney Street, Cambridge, MA 02139
8:00-9:00 Continental breakfast
Session IV: Role of bone marrow-derived cell lineages in growth of the primary tumor and metastatic dissemination
9:00-10:00 Keynote speaker: Lisa Coussens, Ph.D. (UCSF, San Francisco, CA, USA)
(45 min seminar, 15 min Q&A)
Title: “Inflammation & Cancer: Reprogramming Immune Response in Solid Tumors”
10:00-10:30 Coffee break and check-out
10:30-12:00 Hot Topics (15 min talk + 5 min Q&A per speaker)
Aubie Shaw (Vanderbilt): “Myeloid-derived Suppressor Cells Direct Fibroblast Migration and Mammary Carcinoma Cell Invasion”
Virna Cortez-Retamozo (MGH-Harvard): “Origins of Tumor-associated macrophages”
Tania Patsialou (Einstein): “CSF1-receptor in tumor cells and macrophages: autocrine and paracrine mechanisms of invasion and dissemination in breast cancer”
Michael Quante (Columbia): “Role of bone marrow derived myofibroblasts and mesenchymal stem cells in tumorigenesis”
12:00-1:00 Closing remarks and adjourn
-Aubie Shaw and Alexandra Naba, Meeting Co-Chairs
~TMEN JI web page
~TMEN shared resources
1:00-3:00 Bag lunch and post-meeting discussion
